Increased Fatigue in Sarcoglycan Knock Out Mouse Skeletal Muscle Fibers
نویسندگان
چکیده
منابع مشابه
The sarcoglycan complex in skeletal muscle.
In skeletal muscle, the dystrophin-associated glycoprotein complex forms a link between the actin cytoskeleton and the extracellular matrix that is critical for muscle integrity. Within this complex resides the sarcoglycan subcomplex, which consists of four transmembrane glycoproteins (alpha-, beta-, gamma-, and delta-sarcoglycan). During assembly, beta-sarcoglycan tightly associates with delta...
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The sarcoglycan-sarcospan complex (alpha-, beta-, gamma-, delta-, epsilon-, and zeta-SG-SSPN), a component of the dystrophin-associated glycoprotein complex (DAGC), is located at the sarcolemma of muscle fibers where it contributes to maintain cell integrity during contraction-relaxation cycles; gamma- and delta-SG are also expressed in the sarcoplasmic reticulum (SR). In this study, we report ...
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The family with sequence similarity 65, member B (Fam65b) protein is thought to facilitate fusion of myocytes and formation of myotubes during the differentiation of human myogenic cells. Fam65b and histone deacetylase 6 (HDAC6) coimmunoprecipitate and together regulate the levels of acetylated tubulin, which might control microtubule stability in myogenic cells. In this thesis, to gain further...
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Elisabeth C. Nilsson, Yun Chau Long, Sofia Martinsson Stephan Glund, Pablo Garcia-Roves, L. Thomas Svensson, Leif Andersson, Juleen R. Zierath, Margit Mahlapuu From Arexis AB, Göteborg, Sweden, and the Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and the Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden Running Ti...
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Thanks to genomics, we have previously identified markers of beef tenderness, and computed a bioinformatic analysis that enabled us to build an interactome in which we found Hsp27 at a crucial node. Here, we have used a network-based approach for understanding the contribution of Hsp27 to tenderness through the prediction of its interactors related to tenderness. We have revealed the direct int...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.3909